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<br> Depression. Many studies have found St. John's wort to be helpful in treating mild to reasonable depression. St. John's wort can treat mild to average depression. Somatic symptom disorder. Some studies have found that St. John's wort may assist deal with this condition. Triptans. Don't take St. John's wort with these medicines that deal with migraines. Photosensitizing medicines. If you take St. John's wort with medication that will increase sensitivity to sunlight, called photosensitizing drugs, it would raise the risk of a reaction. If you're taking St. John's wort with tacrolimus (Prograf, Astagraf XL, others) or cyclosporine (Neoral, Sandimmune, others), it would lessen the medicine's effect. If you're taking St. John's wort with one of those anti-HIV medicines, it could lessen the medicine's impact. If you're taking St. John's wort with this antidepressant, it might lessen the medication's effect. Barbiturates. If St. John's wort is taken with a medicine that acts as a central nervous system depressant, known as a barbiturate, it might lessen the amount of sleep time the medicine causes.<br>
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